ABSTRACT
Neurotoxicants and environmental pollutants cause neuronal damage and may damage myelin sheath. Since Methyl cobalamine [B12] has effect on myelin sheath formation it was hypothesized that B12 administration in case of nerve damage by some neurotoxicants may be protected or corrected by B12 administration. [Braun, 1977 and Braun, 1980]. For generations physicians have recommended B-vitamins especially B12 for neuropsychiatric symptoms. In present study neuroprotective role of B12 is assessed. Present work was planned to evaluate the therapeutic or prophylactic role of B12 in nerve damage by neurotoxicant i.e. glutamic acid. Present study revealed no significant neuroprotection or defensive regimen offered by B12 for neurotoxic damage. Glutamic acid is probably affecting neurons or dentritis sparing myelin sheath. Neuroprotection expected by B12 may be applied only to myelin sheath
ABSTRACT
Gleason's tumour grade has been accepted as a benchmark protocol in qualifying prostate cancer on histology. Since cyto-evaluation of suspected prostatic malignancy is being increasingly accepted, we have attempted a correlation between cytologic smear pattern categories and Gleason's grade, accorded on cytologic and histologic material and obtained from the same patient, simultaneously in 60 patients. The cytologic smears were classified as 1 well differentiated, corresponding to combined Gleason score 2-4, II moderately differentiated, Gleason 5-7, and III poorly differentiated, corresponding to Gleason 8-10. An overall concordance of 89% was observed between grading on cytologic and histologic material. The incidence of metastases and progression of clinical stage were also found to be clearly influenced by the cytologically accorded grade